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Rational Drug Design: Methods and Protocols
Over the past three decades there have been new developments in therapeutic drug design. In \\\\\\\Rational Drug Design: Methods and Protocols\\\\\\\, expert researchers in the field detail many of the methodologies used to study rational drug design. These include methods such as virtual screening...
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| বিন্যাস: | Printed Book |
| প্রকাশিত: |
New York
Humana Press
2012
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| মালা: | Methods in molecular biology (Clifton, N.J.), v. 928.; Springer protocols (Series)
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| বিষয়গুলি: |
সূচিপত্রের সারণি:
- On setting up and assessing docking simulations for virtual screening / Jacek Biesiada, Aleksey Porollo, and Jaroslaw Meller
- Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling / Jufang Shan and Jie J. Zheng
- Rational design of Rho GTPase-targeting inhibitors / Xun Shang and Yi Zheng
- Rational design of peptide ligands against a glycolipid by NMR studies / Wenyong Tong [and others]
- Combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors / Sheng Zhang [and others]
- Identification of allosteric inhibitors of p21-activated kinase / Julien Viaud and Jeffrey R. Peterson
- Using a modified yeast two-hybrid system to screen for chemical GEF inhibitors / Anne Blangy and Philippe Fort
- Random mutagenesis of peptide aptamers as an optimization strategy for inhibitor screening / Nathalie Bouquier [and others]
- Screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor / Charles S. Craik and Tina Shahian
- Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1 / Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi
- Affinity purification of protein kinases that adopt a specific inactive conformation / Pratistha Ranjitkar and Dustin J. Maly
- Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases / Sanjay B. Hari, Pratistha Ranjitkar, and Dustin J. Maly
- Purification and specific assays for measuring APE-1 endonuclease activity / Adrian Esqueda [and others]
- In vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents / Mohammad Azam
- Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells / Chinavenmeni S. Velu and H. Leighton Grimes
- Synthesis, conjugation, and labeling of multifunctional pRNA nanoparticles for specific delivery of siRNA, drugs, and other therapeutics to target cells / Peixuan Guo [and others]
- Mouse models for tumor metastasis / Shengyu Yang, J. Jillian Zhang, and Xin-Yun Huang.