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Computational Toxicology Volume II
Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing applied and basic science, from streamlining drug efficacy and safet...
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| Format: | Printed Book |
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Humana Press
2013
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| Series: | Methods in Molecular Biology 930
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Table of Contents:
- Methods for building QSARs / James Devillers. Accessing and using chemical databases / Nikolai Nikolov ... [et al.] From QSAR to QSIIR : searching for enhanced computational toxicology models / Hao Zhu. Mutagenicity, carcinogenicity, and other end points / Romualdo Benigni ... [et al.] Classification models for safe drug molecules / A.K. Madan, Sanjay Bajaj, and Harish Dureja. QSAR and metabolic assessment tools in the assessment of genotoxicity / Andrew P. Worth, Silvia Lapenna, and Rositsa Serafimova. Gene expression networks / Reuben Thomas and Christopher J. Portier. Construction of cell type-specific logic models of signaling networks using CellNOpt / Melody K. Morris, Ioannis Melas, and Julio Saez-Rodriguez. Regulatory networks / Gilles Bernot, Jean-Paul Comet, and Christine Risso-de Faverney. Computational reconstruction of metabolic networks from KEGG / Tingting Zhou. Biomarkers / Harmony Larson ... [et al.] Biomonitoring-based environmental public health indicators / Andrey I. Egorov, Dafina Dalbokova, and Michal Krzyzanowski. Modeling for regulatory purposes (risk and safety assessment) / Hisham El-Masri. Developmental toxicity prediction / Raghuraman Venkatapathy and Nina Ching Y. Wang. Predictive computational toxicology to support drug safety assessment / Luis G. Valerio Jr. Developing a practical toxicogenomics data analysis system utilizing open-source software / Takehiro Hirai and Naoki Kiyosawa. Systems toxicology from genes to organs / John Jack, John Wambaugh, and Imran Shah. Agent-based models of cellular systems / Nicola Cannata ... [et al.] Linear algebra / Kenneth Kuttler. Ordinary differential equations / Jiří Lebl. On the development and validation of QSAR models / Paola Gramatica. Principal components analysis / Detlef Groth ... [et al.] Partial least squares methods : partial least squares correlation and partial least square regression / Hervé Abdi and Lynne J. Williams. Maximum likelihood / Shuying Yang and Daniela De Angelis. Bayesian inference / Frederic Y. Bois.