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Systems Biology : Constraint based Reconstruction and Analysis
Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematica...
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| Format: | Printed Book |
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Cambridge, United Kingdom
Cambridge University
2015
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Table of Contents:
- Introduction
- Part 1: Network Reconstruction
- Network Reconstruction: The Concept
- Network Reconstruction: The Process
- Metabolism in Escherichia coli
- Prokaryotes
- Eukaryotes
- Biochemical Reaction Networks
- Metastructures of Genomes
- Part 2: Mathematical Properties of Reconstructed Networks
- The Stoichiometric
- Simple Topological Network Properties
- Fundamental Network Properties
- Fundamental Network Properties
- Pathways
- Use of Pathway Vectors
- Randomized Sampling
- Part 3: Determining the Phenotypic Potential of Reconstructed Networks
- Dual Causality
- Functional States
- Constraints
- Optimization
- Determining Capabilities
- Equivalent States
- Distal Causation
- Part 4: Basic and Applied Uses
- Environmental Parameters
- Genetic Parameters
- Analysis of Omic Data
- Model-Driven Discovery
- Adaptive Laboratory Evolution
- Model-driven Design
- Part 5: Conceptual Foundations
- Teaching Systems Biology
- Epilogue.