Next-Generation DNA Sequencing Informatics

Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many re...

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Bibliographic Details
Main Author: Stuart M Brown
Format: Printed Book
Published: New York Cold Spring Harbor Laboratory Press 2013
Subjects:
Nucleotide sequence. Bioinformatics.
Table of Contents:
  • Preface
  • Acknowledgments
  • About the Authors
  • 1. Introduction to DNA Sequencing / Stuart M. Brown
  • 2. History of Sequencing Informatics / Stuart M. Brown
  • 3. Visualization of Next-Generation Sequencing Data / Phillip Ross Smith, Kranti Konganti, Stuart M. Brown
  • 4. DNA Sequence Alignment / Efstratios Efstathiadis
  • 5. Genome Assembly Using Generalized de Bruijn Digraphs / D. Frank Hsu
  • 6. De Novo Assembly of Bacterial Genomes from Short Sequence Reads / Silvia Argimón, Stuart M. Brown
  • 7. Genome Annotation / Steven Shen
  • 8. Using NGS to Detect Sequence Variants / Jinhua Wang, Zuojian Tang, Stuart M. Brown
  • 9. ChIP-seq / Zuojian Tang, Christina Schweikert, D. Frank Hsu, Stuart M. Brown
  • 10. RNA Sequencing with NGS / Stuart M. Brown, Jeremy Goecks, James Taylor
  • 11. Metagenomics / Alexander Alekseyenko, Stuart M. Brown
  • 12. High-Performance Computing in DNA Sequencing Informatics / Efstratios Efstathiadis, Eric R. Peskin
  • Glossary
  • Index.

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