Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of Chemical Building Blocks on ADMET

Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists...

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Bibliographic Details
Main Author: Dennis Allen Smith [ editor ]
Other Authors: Royal Society of Chemistry (Great Britain)
Format: Printed Book
Published: Cambridge [England] Royal Society of Chemistry ( RSC ) 2010
Series:RSC drug discovery series, no. 1.
Subjects:
Pharmacokinetics. Drugs > Metabolism. Functional groups.
Table of Contents:
  • Drugs and their structural motifs
  • ADMET for the medicinal chemist
  • Carboxylic acids and their bioisosteres
  • Primary, secondary, and tertiary amines and their isosteres
  • Sulfonamide as an essential functional group in drug design
  • Influence of aromatic rings on ADME properties of drugs
  • Influence of heteroaromatic rings on ADME properties
  • Peptidomimetics and peptides as drugs: motifs incorporated to enhance drug characteristics
  • Pharmacokinetics and metabolism of compounds that mimic enzyme transition states
  • Alcohols and phenols: absorption, distribution, metabolism, and excretion
  • Future targets and chemistry and ADME needs.

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