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Structural Bioinformatics
"[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also...
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| Format: | Printed Book |
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Wiley-Liss
2003
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| LEADER | 03728nam a2200181Ia 4500 | ||
|---|---|---|---|
| 999 | |c 26911 |d 26911 | ||
| 020 | |a 9780471201991 | ||
| 082 | |a 572.8733 BOU-S | ||
| 100 | |a Philip E Bourne | ||
| 245 | |a Structural Bioinformatics | ||
| 260 | |b Wiley-Liss |c 2003 | ||
| 300 | |a xix, 649 pages, [32] pages of plates : illustrations (some color) ; 26 cm. | ||
| 505 | |a Defining bioinformatics and structural bioinformatics / Russ B. Altman, Jonathan M. Dugan -- Fundamentals of protein structure / Eric D. Scheeff, J. Lynn Fink -- Fundamentals of DNA and RNA structure / Stephen Neidle, Bohdan Schneider, Helen M. Berman -- Computational aspects of high-throughput crystallographic macromolecular structure determination / Paul D. Adams, Ralf W. Grosse-Kunstleve, Axel T. Brunger -- Macromolecular structure determination by NMR spectroscopy / John L. Markley [and others] -- Electron microscopy / Niels Volkmann, Dorit Hanein -- Molecular visualization / John Tate -- The PDB format, mmCIF, and other data formats / John D. Westbrook, P.M.D. Fitzgerald -- The protein data bank / The PDB team -- The nucleic acid database / Helen M. Berman [and others] -- Other structure-based databases / Helge Weissig, Philip E. Bourne -- Protein structure evolution and the SCOP database / Boojala V.B. Reddy, Philip E. Bourne -- The CATH domain structure database / C.A. Orengo, F.M.G. Pearl, J.M. Thornton -- Structural quality assurance / Roman A. Laskowski -- All-atom contacts: a new approach to structure validation / Jane S. Richardson -- Structure comparison and alignment / Philip E. Bourne, Ilya N. Shindyalov -- Secondary structure assignment / Claus A.F. Andersen, Burkhard Rost -- Identifying structural domains in proteins / Lorenz Wernisch, Shoshana J. Wodak -- Inferring protein function from structure / Gail J. Bartlett, Annabel E. Todd, Janet M. Thornton -- Prediction of protein-protein interactions from evolutionary information / Alfonso Valencia, Florencio Pazos -- Electrostatic interactions / Nathan A. Baker, J. Andrew McCammon -- Principles and methods of docking and ligand design / J. Krumrine [and others] -- Structural bioinformatics in drug discovery / Eric B. Fauman, Andrew L. Hopkins, Colin R. Groom -- CASP and CAFASP experiments and their findings / Philip E. Bourne -- Homology modeling / Elmar Krieger, Sander B. Nabuurs, Gert Vriend -- Fold recognition methods / Adam Godzik -- Ab initio methods / Dylan Chivian [and others] -- Prediction in 1D: secondary structure, membrane helices, and accessibility / Burkhard Rost -- Structural genomics / Stephen K. Burley, Jeffrey B. Bonanno. | ||
| 520 | |a "[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery." This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies. | ||
| 650 | |a Structural bioinformatics. Computational Biology. Molecular Biology. | ||
| 700 | |a Helge Weissig | ||
| 942 | |c BK | ||
| 952 | |0 0 |1 0 |4 0 |6 572_873300000000000_BOUS |7 0 |9 29470 |a DCB |b DCB |d 2015-09-01 |l 2 |o 572.8733 BOU-S |p DCB273 |r 2019-02-26 |s 2019-01-04 |w 2019-07-19 |y BK | ||