Cap-analysis gene expression (CAGE) : the science of decoding gene transcription /

"The ouput of eukaryotic genomes is much more complex than expected. Genes produce different variants of RNAs from multiple promoters. One of the ultimate targets of biological analysis is to establish a relationship between the messenger RNAs that are transcribed from the genome and the genomi...

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Bibliographic Details
Other Authors: Carninci, Piero
Format: Printed Book
Published: Singapore : Pan Stanford, c2010.
Subjects:
Gene expression.
Table of Contents:
  • Cap analysis gene expression (CAGE)
  • Tagging transcription starting sites with CAGE
  • Construction of CAGE libraries
  • Transcriptome and genome characterization using massively parallel paired end tag (PET) sequencing analysis
  • New era of genome-wide gene expression analysis
  • Computational tools to analyze CAGE
  • Extraction and quality control of CAGE tags
  • Setting CAGE tags in a genomic context
  • Using CAGE data for quantitative expression
  • Databases for CAGE visualization and analysis
  • Computational methods to identify transcription factor binding sites using CAGE information
  • Transcription regulatory networks analysis using CAGE
  • Gene-expression ontologies and tag-based expression profiling
  • Lessons learned from genomic CAGE
  • Future challenges in CAGE analysis
  • Comparative genomics and mammalian promoter evolution
  • The impact of CAGE data on understanding macrophage transcriptional biology.

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