Kinase inhibitor drugs /

Bibliographic Details
Other Authors: Li, Rongshi, Stafford, Jeffrey A.
Format: Printed Book
Language:English
Published: Hoboken, N.J. : Wiley, c2009.
Series:Wiley series in drug discovery and development.
Subjects:
Protein kinases
Antineoplastic agents.
Neoplasms
Protein Kinase Inhibitors
Antineoplastic Agents
Drug Discovery.
Protein Kinases
Table of Contents:
  • The discovery and development of sunitinib (SU11248) : a multitarget tyrosine kinase inhibitor of tumor growth, survival, and angiogenesis / Connie L. Sun, James G. Christensen, and Gerald McMahon
  • Tykerb discovery : a dual EGFR and ERBB2 tyrosine kinase inhibitor / Karen Lackey and G. Stuart Cockerill
  • Discovery of pazopanib : a pan vascular endothelial growth factor kinase inhibitor / Philip A. Harris and Jeffrey A. Stafford
  • The road to ABT-869 : a multitargeted receptor tyrosine kinase inhibitor / Michael Michaelides and Daniel H. Albert
  • Discovery of motesanib / Andrew S. Tasker and Vinod F. Patel
  • Discovery of brivanib alaninate : a dual vascular endothelial growth factor and fibroblast growth factor receptor inhibitor / Rajeev S. Bhide and Joseph Fargnoli
  • Structure-based design and characterization of axitinib / Robert S. Kania
  • The road to PD0325901 and beyond : the MEK inhibitors quest / Judith S. Sebolt-Leopold and Alexander J. Bridges
  • Discovery of allosteric MEK inhibitors / Eli Wallace and James F. Blake
  • Discovery of MK-0457 (VX-680) / Julian M.C. Golec
  • Discovery of PHA-739358 / Daniele Fancelli and Jürgen Moll
  • Discovery of AZD1152 : a selective inhibitor of aurora-B kinase with potent antitumor activity / Kevin M. Foote and Andrew A. Mortlock
  • Case study of aurora-A inhibitor MLN8054 / Christopher F. Claiborne and Mark G. Manfredi
  • Discovery of GSK461364 : a polo-like kinase 1 inhibitor for the treatment of cancer / Kevin W. Kuntz and Kyle A. Emmitte
  • Pharmacogenomics of dasatinib (Sprycel) / Fei Huang and Edwin A. Clark
  • Practical use of computational chemistry in kinase drug discovery / James M. Veal
  • Approaches to kinase homology modeling : successes and consideration for the structural kinome / Victoria A. Feher and J. David Lawson
  • Fragment-based drug discovery of kinase inhibitors / Daniel A. Erlanson
  • Protein kinase structural biology : methods and strategies for targeted drug discovery / Clifford D. Mol, Kengo Okada, and David J. Hosfield.

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