Green techniques for organic synthesis and medicinal chemistry /

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Bibliographic Details
Other Authors: Zhang, Wei (Editor), Cue, Berkeley W. (Editor)
Format: Printed Book
Language:English
Published: New Jersey : John Wiley, c2018
Edition:Second edition.
Subjects:
Pharmaceutical chemistry.
Green chemistry.
MEDICAL / Pharmacology.
Electronic books.
Online Access:Wiley Online Library - Full text
Table of Contents:
  • Intro; Green Techniques for Organic Synthesis and Medicinal Chemistry; Contents; List of Contributors; Foreword; Preface; Part I General Topics in Green Chemistry; 1 Green Chemistry Metrics; 1.1 Business Case; 1.2 Historical Context; 1.3 Metrics, Awards, and Barriers; 1.3.1 Mass-Based Metrics; 1.3.2 Life-Cycle Assessment; 1.3.3 Green Analytical Chemistry (GAC); 1.3.4 Awards; 1.3.5 Barriers; 1.4 Metrics Unification Via Green Aspiration Level; 1.4.1 Standardizing Metrics; 1.4.2 Defining Analysis Starting Points; 1.4.3 Considering Drug Manufacturing Complexity; 1.4.4 Green Aspiration Level (GAL)
  • 2.3.3 Dimethylisosorbide2.3.4 Butanol; 2.3.5 Ethyl Lactate and Lactic Acid; 2.3.6 Glycerol and Glycerol Derivatives; 2.3.7 Cyrene; 2.3.8 2-Methyl Tetrahydrofuran; 2.3.9 Cyclopentyl Methyl Ether; 2.4 Opportunities, Challenges, and Future Developments; References; 3 Green Analytical Chemistry; 3.1 Introduction; 3.1.1 Analytical Method Assessment; 3.1.2 Case Studies; 3.2 Sample Preparation; 3.2.1 Sample Preparation Focusing on Liquid Approaches; 3.2.2 Sample Preparation Using Solid Supports; 3.3 Techniques and Methods; 3.3.1 Liquid Chromatography; 3.3.2 Gas Chromatography
  • 3.3.3 Supercritical Fluid Chromatography3.3.4 Spectroscopy; 3.4 Process Analytical Technology; 3.5 Biopharmaceutical Analysis; 3.5.1 Biopharmaceutical Sample Preparation; 3.5.2 Chromatographic and Electrophoretic Separation; 3.5.3 PAT for Biopharmaceuticals; 3.6 Conclusions; Acknowledgments; References; 4 Green Engineering; 4.1 Introduction: Green Engineering Misconceptions and Realizations; 4.2 12 Principles of Green Engineering; 4.3 Green Chemistry Metrics Applied to Engineering; 4.3.1 Maleic Anhydride Production Example; 4.3.2 Level 1 Green Chemistry Metrics
  • 4.3.3 Level 2 Green Chemistry Metrics4.3.4 Level 3 Green Chemistry Metrics; 4.4 Use of Green Solvents in the Chemical Industry; 4.4.1 Waste Prevention; 4.4.2 Inherently Non-Hazardous; 4.4.3 Renewable Rather Than Depleting; 4.4.4 Design for Commercial After-Life; 4.4.5 Separation and Purification to Minimize Energy Consumption and Materials Use; 4.4.6 Integration and Interconnectivity with Available Energy and Materials Flows; 4.4.7 Conserve Complexity; 4.5 Presidential Green Chemistry Awards; 4.6 Opportunities and Outlook; References; 5 Greening of Consumer Cleaning Products

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