An introduction to medicinal chemistry /

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For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actual...

Ausführliche Beschreibung

Bibliographische Detailangaben
1. Verfasser: Patrick, Graham L.
Format: Printed Book
Sprache:English
Veröffentlicht: Oxford ; New York : Oxford University Press, 2001.
Ausgabe:2nd ed.
Schlagworte:
Pharmaceutical chemistry
Online Zugang:https://india.oup.com/product/an-introduction-to-medicinal-chemistry-9780198796589?
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100 1 |a Patrick, Graham L.  |9 23507 
245 1 3 |a An introduction to medicinal chemistry /  |c Graham L. Patrick. 
250 |a 2nd ed. 
260 |a Oxford ;  |a New York :  |b Oxford University Press,  |c 2001. 
300 |a xxiii, 620 p. :  |b ill. ;  |c 25 cm. 
504 |a Includes bibliographical references (p. [598]) and index. 
505 |a Chapters 1. Drugs and drug targets: an overview -- Part A - Drug Targets, Pharmacodynamics and Pharmacokinetics -- 2. Protein structure and function -- 3. Enzymes and enzyme inhibitors -- 4. Receptors, agonists and antagonists -- 5. Receptors and signal transduction -- 6. Nucleic acids as drug targets -- 7. Miscellaneous drug targets -- 8. Pharmacokinetics and related topics -- -- Part B - Drug Discovery, Design, and Development -- 9. Drug discovery: finding a lead -- 10. Drug design: optimizing target interactions -- 11. Drug design: optimizing access to the target -- 12. Getting the drug to market -- -- Part C - Selected Topics in Medicinal Chemistry -- 13. Cholinergics, anticholinergics, and anticholinesterases -- 14. Drugs acting on the adrenergic nervous system -- 15. Opioid analgesics -- 16. Antiulcer agents -- 17. Antibacterial agents -- 18. Antiviral agents -- 19. Anticancer agents -- -- Part D - Tools of the Trade -- 20. Combinatorial synthesis -- 21. Computers in medicinal chemistry -- 22. Quantitative structure-activity relationships (QSAR)  
520 2 |a For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market? An Introduction to Medicinal Chemistry, International Edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part A of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.  
650 0 |a Pharmaceutical chemistry  |9 23508 
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955 |a pb11 2001-07-25 to ASCD  |a jc00 2001-08-06;  |i jc09 2001-09-04  |a aa03 2001-09-17 
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