Genotyping of virus involved in the 2006 Chikungunya outbreak in South India (Kerala and Puducherry

An epidemic outbreak of Chikungunya virus occurred during 2006 in 15 States/Union Territories of India. The magnitude of the outbreak was unprecedented. We carried out a preliminary investigation to characterize the genotype of the virus involved in the outbreak in the State of Kerala and the Union...

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Bibliografiset tiedot
Päätekijä: N. Pradeep Kumar,, M. Madhu Mitha, N. Krishnamoorthy, T. Kamaraj, Rajan Joseph P. Jambulingam
Aineistotyyppi: Printed Book
Julkaistu: CURRENT SCIENCE, VOL. 93, NO. 10, 25 NOVEMBER 2007 2007
Linkit:http://10.26.1.76/ks/002834.pdf
LEADER 017710000a22001330004500
100 |a N. Pradeep Kumar,, M. Madhu Mitha, N. Krishnamoorthy, T. Kamaraj, Rajan Joseph P. Jambulingam 
245 |a Genotyping of virus involved in the 2006 Chikungunya outbreak in South India (Kerala and Puducherry 
260 |c 2007 
260 |b CURRENT SCIENCE, VOL. 93, NO. 10, 25 NOVEMBER 2007 
520 |a An epidemic outbreak of Chikungunya virus occurred during 2006 in 15 States/Union Territories of India. The magnitude of the outbreak was unprecedented. We carried out a preliminary investigation to characterize the genotype of the virus involved in the outbreak in the State of Kerala and the Union Territory of Puducherry. We also looked into mutations in the gene sequences of the E1 region, the most informative gene of the virus on phylogeny, so as to understand the evolutionary trends of the species. The results indicate that the outbreak in Kerala and Puducherry was caused by the East Central South African (ECSA) strain of the virus. Owing to the absence of the A226Vmutation in the samples analysed, it is likely that the outbreak was caused by the introduction of the ancestral stock of the Reunion clade to India, either by a human host or by the vector population. The magnitude of the outbreak might be due to mutations other than the already proposed one, i.e. A226V. Interestingly, one of the samples (Puducherry) showed a mutation K211E in the E1 gene, specific only to the Asian strain. In-depth studies are required in order to have a thorough understanding of the phylogenetic trends of the virus in India.  
856 |u http://10.26.1.76/ks/002834.pdf 
942 |c KS 
999 |c 72222  |d 72222 
952 |0 0  |1 0  |4 0  |7 0  |9 64186  |a MGUL  |b MGUL  |d 2015-08-01  |l 0  |r 2015-08-01  |w 2015-08-01  |y KS 

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