Llwytho...
Chromatin deregulation in cancer /
"The machinery that controls how DNA is packaged and genes are activated plays an important role in cancer. This book examines the functions of components of this machinery, how they can be dysregulated, and the prospects for targeting them therapeutically. Highlights include: - PRC2 polycomb...
| Awduron Eraill: | , , |
|---|---|
| Fformat: | Printed Book |
| Cyhoeddwyd: |
New York:
Cold spring harbor laboratory press,
2017.
|
| Pynciau: |
Tabl Cynhwysion:
- Machine generated contents note:
- (preliminary)
- Preface
- Mutations in the machinery
- 1. PRC2 polycomb complex--Kristian Helin
- 2. IDH1/2
- 3. NSD proteins--Jonathan Licht & Jon Oyer
- 4. MLL1-fusion proteins--Scott Armstrong
- 5. Histone H3 mutations--David Allis
- 6. MLL3 and MLL4 COMPASS complexes (include UTX)--Ali Shilatifard
- 7. SWI/SNF--Gerald Crabtree
- 8. DNMT3a--Margaret A. Goodell
- 9. TET2--Ross Levine
- 10. P300/CBP-- Siavash Kurdistani
- 11. ASXL1/2--Omar Abdel-Wahab
- 12. SETD2--Ian Davis
- 13. ATRX/Daxx--Emily Bernstein
- 14. CHDs--Alea Mills
- 15. Cohesins--Ana Losada
- Therapy
- 16. Therapy- HDAC inhibitors--Ed Seto
- 17. Therapy- Lysine Methyltransferases--Ari Melnick
- 18. Therapy- Hypomethylating agents--Jean-Pierre Issa
- 19. Therapy- BET bromodomain inhibitors--Christopher Vakoc
- 20. Therapy- Lysine demethylase inhibitors--Yang Shi
- Conceptual
- 21. Epigenetic mechanisms of therapy resistance and tumor heterogeneity
- 22. DNA methylation and cancer--Steve Baylin
- 23. Epigenetic contributors to copy number changes, genetic heterogeneity in tumors--Johnathan Whetstine
- 24. Nucleosome dynamics and chromatin biology or histone modifications and the control of transcription or inheritance themes--Steve Henikoff
- 25. Non-histone substrates of histone modifying enzymes--Or Gozani
- 26. Long non-coding RNA--Howard Chang
- Index.