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Pathological observations of Ficus tsiela (Rox b) toxicity in rats
The present study entitled ‘Pathological Observations of Ficus tsiela (Rox b) Toxicity in rats’ was undertaken by administering the animals with different concentrations of fresh juice and alcoholic extract for a period of 21 days. The weekly body weights, clinical signs, haematology, biochemical pa...
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| Format: | Ph.D Thesis |
| Language: | Undetermined |
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Mannuthy
Centre for Excellence in Pathology, College of Veterinary and Animal Sciences
2009
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| 245 | |a Pathological observations of Ficus tsiela (Rox b) toxicity in rats | ||
| 260 | |a Mannuthy |b Centre for Excellence in Pathology, College of Veterinary and Animal Sciences |c 2009 | ||
| 300 | |a 82 | ||
| 502 | |b MVSc | ||
| 520 | 3 | |a The present study entitled ‘Pathological Observations of Ficus tsiela (Rox b) Toxicity in rats’ was undertaken by administering the animals with different concentrations of fresh juice and alcoholic extract for a period of 21 days. The weekly body weights, clinical signs, haematology, biochemical parameters, gross pathology and histopathology of various organs were analysed to study the effect. Phytochemical evaluation of the fresh juice and extract was done and the oxidative damage of the liver was assessed by the estimation of lipid peroxides and reduced glutathione. Phytochemical evaluation of the fresh juice revealed the presence of detectable levels of tannins, glycosides, diterpenes, triterpenes, alkaloids, flavonoids and phenolic compounds whereas the ethanolic extract revealed the presence of tannins, phenolic compounds, diterpenes and triterpenes. The animals remained clinically normal throughout the experimental period and the body weight revealed a gradual increase. Hb, PCV, TLC and DLC revealed no variation whereas ALP, creatinine and CK values showed a significant increase in the higher dose groups. There was no variation in the level of blood sugar. There was an increase in the lipid peroxides and reduction in the glutathione in the liver homogenate which indicated oxidative damage. Gross lesions were not observed in the internal organs except congestion and diffuse enlargement of the kidney and liver in the highest dose group. Focal necrotic spots were present in the liver. Tubular and glomerular degeneration and necrosis of the kidney, sinusoidal congestion and multifocal necrosis of the liver, depletion of colloid and variation in the size of follicles of the thyroid gland, medullary cyst in the adrenal gland, goblet cell hyperplasia of intestine, intermuscular haemorrhage in the heart, reactive spleen with multiple cortical follicles with germinal centres, peribronchial lymphoid hyperplasia in the lungs were the lesions observed. The brain, spinal cord and pituitary did not reveal any signs of intoxication. The study revealed that the fresh juice and ethanolic extract at higher doses are nephro-hepatotoxic but not neurotoxic to rats. | |
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